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. Author manuscript; available in PMC: 2013 Nov 1.
Published in final edited form as: Biomaterials. 2012 Aug 19;33(33):8265–8276. doi: 10.1016/j.biomaterials.2012.07.041

Fig. 10. Synergy prediction on dual combinations of Wnt, BMP2, and TGFβ based on Bliss combination index.

Fig. 10

Wnt and BMP2 perform dose-dependent synergism. (a) BMP2 levels governed the synergism. When the BMP2 level was higher than 0, the two drugs were synergic, otherwise antagonistic. We also found that Wnt at high levels showed opposite effects in terms of synergism at different BMP2 levels. When BMP2 level was high, increasing Wnt level promoted the synergistic effects of the two drugs. In contrast, when BMP2 level was low, the more the Wnt was introduced, the stronger the antagonistic effect was. (b) Wnt/TGFβ and (c) BMP2/TGFβ combinations also showed dose-dependent synergism but much lower responses.