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. Author manuscript; available in PMC: 2013 Nov 1.
Published in final edited form as: Biomaterials. 2012 Aug 19;33(33):8265–8276. doi: 10.1016/j.biomaterials.2012.07.041

Fig. 6. The responses of cell population and bone mass to the change of single cytokine concentration.

Fig. 6

(a) increased Wnt, (b) increased BMP2 and (c) increased TGFβ by 10 folds respectively from the 50th days to the 150th days. (a) When the concentration of Wnt was increased, both concentrations of pre-osteoblasts and active osteoblasts increased rapidly; whereas the concentration of pre-osteoclasts was almost invariant. (b) When the concentration of BMP2 was increased, the concentration of active osteoblasts increased significantly and the concentration of osteoclasts decreased greatly whereas both concentrations of pre-osteoblasts and pre-osteoclasts were almost invariant. (c) When the concentration of TGF-β was increased a much lower response was observed. (d) The bone mass increased most when the concentration of BMP2 was increased.