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. Author manuscript; available in PMC: 2013 Nov 1.
Published in final edited form as: Biomaterials. 2012 Aug 19;33(33):8265–8276. doi: 10.1016/j.biomaterials.2012.07.041

Fig. 9. Synergy prediction on Wnt and BMP2 combination based on Loewe combination index.

Fig. 9

5% isobologram of Wnt and BMP2 (green curve) bows inward indicating CI<1, therefore the combination of Wnt and BMP2 is synergy. The optimal combination of Wnt and BMP2 in terms of the minimum total dose to achieve 5% bone mass growth was marked in red at (d1, d2).