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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: Aging Cell. 2012 Jun 11;11(5):732–740. doi: 10.1111/j.1474-9726.2012.00836.x

Figure 1.

Figure 1

Proliferation and priming of OTII donor cells in young and aged hosts. (A) CFSE-dilution profile of OTII donor cells recovered from the spleen and lymph nodes of young and aged hosts 1, 2, 3 and 4 days post-immunization. Histograms represent concatenated data from 4-5 mice per time point. (B) Percentage of OTII donor cells expressing CD69+ and (C) total number of OTII donor cells recovered from the spleen of young and aged hosts 12 to 120 hours post-immunization. Each time point represents the mean ± sem of 4-5 mice per group of one representative experiment out of 2. Statistical significance was determined by 2-way Anova (Age and Time) followed by Bonferroni’s posttests *, p<0.05; ***, p<0.001 of young vs aged groups. The interaction between age and time was extremely significant (p<0.0001).