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. 2012 May;17(5):344–364. doi: 10.1111/j.1365-2443.2012.01596.x

Figure 4.

Figure 4

Attenuation of autoimmunity in mouse models by anti-IL-17A aptamer (Ishiguro et al. 2011). (A) Suppression of experimental autoimmune encephalitis (EAE) development by Apt21-2 (Ishiguro et al. 2011). Wild-type mice (n = 10 each) were immunized with myelin oligodendrocyte protein (MOG35–55) peptide in complete Freund’s adjuvant, and PEG21-2idT (0, 1, 3 and 10 mg/kg) was administered i.p. every other day after immunization. EAE clinical scores for vehicle and PEG21-2idT–administered mice. Values are the mean and SEM of 10 mice per group. (B) PEG21-2idT treatment suppresses development of glucose-6-phosphate isomerase (GPI)-induced arthritis. DBA/1 mice were immunized with 300 μg of mouse GPI, and the development of arthritis was monitored visually and scored on a scale of 0–2. Values are the mean and SEM of 10 mice per group.