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ERp57 inhibition reduces platelet fibrinogen binding. Fibrinogen binding to integrin αIIbβ3 in the presence of either pre-immune IgG (37.5 μg mL−1, filled histogram) or anti-ERp57 (37.5 μg mL−1, open histogram was measured by flow cytometry. Human platelets were stimulated with CRP-XL (1 μg mL−1) and ligated fibrinogen detected using FITC-labelled anti-fibrinogen antibody (A). Fluorescence data for pre-immune IgG and anti-ERp57 treated cells from 3 platelet donors (B), *P < 0.05.
