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. 2012 Feb;10(2):278–288. doi: 10.1111/j.1538-7836.2011.04593.x

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© 2011 International Society on Thrombosis and Haemostasis

Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.

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Fig. 7 — ERp57 modulates arterial thrombus formation in vivo. The presence of ERp57 in thrombi and its role in arterial thrombus formation was examined by intravital microscopy using a laser injury model. Alexa-488 labelled control-IgG (A) or anti-ERp57 (B) were infused into C57/BL6 mice, and following laser injury images were captured over 2 min of thrombus formation (n = 3). (C) The effect of anti-ERp57 on arterial thrombus formation was quantified following laser injury in mice treated with Alexa-488 anti-GPIb-conjugated antibody. Arrows denote the site of the thrombus. Peak integrated thrombus fluorescence measurements for thrombi formed in the presence of anti-ERp57 (open histogram) treated mice were compared to those obtained for control IgG (closed histogram). n = 24, ***P < 0.005.