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. 2012 Apr;17(4):249–263. doi: 10.1111/j.1365-2443.2012.01587.x

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© 2012 The Authors. Journal compilation © 2012 by the Molecular Biology Society of Japan/Blackwell Publishing Ltd

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Distinct functions of three members of the vertebrate ATF-2 family. (A) Homology between three members of the vertebrate ATF-2 family. (B) Two different functions of the ATF-2 transcription factor family. ATF-2 activates transcription in response to various stresses by interaction with the coactivator, CBP, which induces the acetylation of histones. In the absence of stress, ATF-7 silences transcription via interaction with the histone H3-K9 trimethyltransferase ESET (SETDB1), which forms a heterochromatin-like structure.