Table 2.

Physiological role of ATF-2 family transcription factors

Member of ATF-2 family	Mutant	Phenotype	References
Mouse ATF-2	Null mutant	Neonatal lethal/placental defect	Maekawa et al. (1999)
Mouse ATF-2	Heterozygous mutant	Mammary tumors	Maekawa et al. (2007)
Mouse ATF-2	Keratinocyte-specific mutant	Skin tumor	Bhoumik et al. (2008)
Mouse ATF-2	Hypomorphic mutant	Chondrodysplasia and neurological abnormalities	Reimold et al. (1996)
Mouse CRE-BPa	Null mutant	Neonatal lethality/lung defect	Maekawa et al. (2010a)
Mouse ATF-2 and CRE-BPa	trans-Heterozygous mutant	Reduced white adipose tissue	Maekawa et al. (2010a)
Mouse ATF-2 and ATF-7	ATF-2 Ala and ATF-7 null mutant	Embryonic lethal/liver and heart defect	Breitwieser et al. (2007)
Mouse ATF-7	Null mutant	Abnormal behavior	Maekawa et al. (2010b)
Drosophila melanogaster ATF-2	PiggyBac insertion	Disruption of heterochromatin	Seong et al. (2011)
D. melanogaster ATF-2	Reduction in fat body	Reduced glyceroneogenesis	Okamura et al. (2007)
D. melanogaster ATF-2	Reduction in pacemaker neurons	Abnormality in sleep and locomotion	Shimizu et al. (2008)
Caenorhabditis elegans ATF-7	Null mutant	Abnormality in innate immunity	Shivers et al. (2010)