Fig. 4.

Type I interferon (IFN) induces CCL5 expression in various vascular endothelial cells (VEC). CCL5 mRNA expression in VEC stimulated with (a) IFN-α (10 ng/ml) or (b) IFN-β (10 ng/ml). (c) CCL5 mRNA expression in VEC stimulated with IFN-α or IFN-β for 24 h. (d) CCL5 protein levels in the culture supernatant of VEC stimulated with IFN-α or IFN-β for 72 h. Induced mRNA expression is indicated as the relative quantity against non-stimulated VEC. Data from three or four independent experiments are presented as mean ± standard error. *P < 0·05; **P < 0·01, ***P < 0·001 in comparison with equally stimulated human umbilical vein endothelial cells (HUVEC).