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. 2012 Sep 18;3:167. doi: 10.3389/fphar.2012.00167

Figure 4.

Figure 4

Effect of parenteral (i.p.) administration of sildenafil (A; 0.7 mg/kg body weight) and of vardenafil (B; 0.14 mg/kg body weight) on CFTR-dependent chloride secretion assessed by means of the nasal potential difference (PD) in wild-type (WT) and F508del-CF mice. Vardenafil stimulates chloride secretion of the wild-type CFTR. The correcting effect of vardenafil lasts at least 24 h. Data are expressed as mean ± SEM of 14–15 placebo treated animals and six animals treated with PDE5 inhibitors (Lubamba et al., 2008).