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Anti-inflammatory effect of in vivo treatment, by i.p. injection, of a single therapeutic dose of vardenafil (vard) to wild-type (A) and F508del-CF (B) mice on the inflammatory response induced by lipopolyssaccharide from P. aeruginosa (LPS). Biosynthesis of CCL-2 is significantly reduced in the bronchoalveolar lavage of vardenafil-treated CF and non-CF animals (Lubamba et al., 2012b).
