Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2012 Sep 17;198(6):991–998. doi: 10.1083/jcb.201203083

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2012 Chartier et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

PMC Copyright notice

Figure 2. — Repression of superoxide production by Crb is crucial for epithelial integrity. (A–L) Panels show a portion of the lateral epidermis of late-stage embryos immunostained for Fasciclin 3 (Fas3; A, C, E, G, I, and K) or a cuticle preparation (B, D, F, H, J, and L) for the following genotypes: wild-type (A and B), crb^11A22 (null allele; C and D), daGAL4/UAS-Sod1 (overexpression of Sod1 in a wild-type background; E and F), crb^11A22, daGAL4/crb^11A22, UAS-Sod1 (overexpression of Sod1 in a crb^11A22 mutant background; G and H), UAS-p35; daGAL4 (expression of BacA/p35 in a wild-type background; I and J), or UAS-p35; crb^11A22/crb^11A22, daGAL4 (expression of BacA/p35 in a crb^11A22 mutant background; K and L). (M and N) Panels show Crb staining (M) or costaining of Crb and Dlg (N; red and green, respectively) in the ventral epidermis of a stage 16 Rac heterozygous mutant embryo (ptcGAL4/+; Rac1^J11, Rac2^Δ, Mtl^Δ/+). (O and P) Crb staining or staining of Crb (red) and Dlg (green) in the ventral epidermis of a stage 16 embryo knockdown for Nox and heterozygous for Rac (ptcGAL4/UAS-shRNA Nox; Rac1^J11, Rac2^Δ, Mtl^Δ/+). Bars: (A, C, E, G, I, and K) 10 µm; (B, D, F, H, J, and L) 100 µm; (M–P) 10 µm.