Table 2. Top markers for rejection in urine samples on Antibody Microarray using the average of normal kidney (NK) and stable function (SF), ratio’ed to chronic (ChrR) or acute (AR) rejection.
Table 1a is sorted by the ratio in urine showing markers most decreased in rejection. Table 1b below is sorted by the ratio in urine showing markers most increased in rejection. Table 1c below is sorted by the ratio in urine showing no change in markers in either state.
| ID | (NK+SF) vs (Chr+AR) | |
|---|---|---|
| Ratio | t-test | |
| a: Decreased in rejection state | ||
| integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) |
13.20 | 0.00009 |
| dynamin 1-like | 12.78 | 1.E-07 |
| RAD9 homolog (S. pombe) | 12.01 | 0.00001 |
| RAN binding protein 3 | 11.55 | 4.E-08 |
| potassium large conductance calcium-activated channel, subfamily M, alpha member 1 | 10.64 | 3.E-07 |
| interleukin 13 | 9.31 | 2.E-10 |
| APEX nuclease (multifunctional DNA repair enzyme) 1 | 8.85 | 0.00003 |
| annexin A11 | 8.75 | 0.00001 |
| translin-associated factor X | 8.60 | 2.E-06 |
| pleckstrin | 8.35 | 6.E-07 |
| TNF receptor-associated factor 4 | 7.90 | 1.E-06 |
| protein kinase C-like 2 | 7.76 | 0.00004 |
| b: Increased in rejection state | ||
| integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | 2.51 | 2.E-06 |
| tumor necrosis factor (TNF superfamily, member 2) | 2.13 | 0.00007 |
| microtubule-associated protein, RP/EB family, member 1 | 1.96 | 0.00001 |
| ATPase, Na+/K+ transporting, beta 3 polypeptide | 1.94 | 5.E-06 |
| integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 1.80 | 0.00006 |
| Cas-Br-M (murine) ecotropic retroviral transforming sequence | 1.80 | 6.E-08 |
| adaptor-related protein complex 2, alpha 1 subunit | 1.79 | 7.E-08 |
| MAD, mothers against decapentaplegic homolog 2 (Drosophila) | 1.76 | 2.E-08 |
| nitric oxide synthase 2A (inducible, hepatocytes) | 1.69 | 0.00004 |
| c: Not Changing in rejection state | ||
| nuclear autoantigenic sperm protein (histone-binding) | 1.02 | 0.92431 |
| Rho GTPase activating protein 1 | −1.02 | 0.06305 |
| caspase 9, apoptosis-related cysteine protease | −1.03 | 0.01703 |
| myogenic factor 3 | 1.07 | 0.00299 |
| nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 1.06 | 0.67978 |
| TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa | 1.07 | 0.21566 |
| nuclear receptor subfamily 4, group A, member 1 | −1.01 | 0.87732 |
| protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) | −1.02 | 0.32573 |