Figure 4.

TG inhibition protects immature cortical neurons from oxidative stress-mediated cell death. A, Structures of four diverse, reversible or irreversible, isoform-nonselective TG inhibitors tested in an in vitro model of oxidative stress. B–D, Cystamine (1–100 μm) (B), B003 (100, 200 μm) (C), and D004 (25–100 μm) (D) protect primary immature cortical neurons against oxidative stress-induced cell death. E, T101, a cell-impermeable TG inhibitor, fails to provide protection. **p < 0.01; ***p < 0.001 compared with glutamate treatment alone; untreated controls are calculated at 100% of survival.