Table 1.

Selected Requirements for Macrophage Arginine Metabolism Transcriptome Regulation

			Slc7a2		iNOS		Ass1		Arg1
Species	Intracellular Lifestyle	Exit Strategy	MyD88 Required	IFN Required	MyD88 Required	IFN Required	MyD88 Required	IFN Required	MyD88 Required	Additional Cytokine Req.
Mycobacterium bovis BCG	Endosomal / Phagosomal	Inhibited cellular egress (as compared to M. tuberculosis)	Yes		Yes	Yes	Yes	?	Yes	IL-6, G-CSF, IL-10
Listeria monocytogenes	Cytosolic	Actin-based protrusion / Pyroptosis Induction	Partial	No	Partial I	Yes	No	?	Yes	Stat3-inducing likely
Francisella tularensis LVS	Cytosolic	Induction of Apoptosis / Pyroptosis	Yes	?	Yes	?	Yes	?	Yes	IL-4, IL-13
Chlamydia psittaci	Endosomal / Inclusion membrane	Cellular lysis / Vacuolar Extrusion	Yes	? _	Yes	?	Yes	?	Not Induced