Table 4.
Correlation between clinico-pathological features and the expressions of Hsp90-beta and annexin A1 in lung cancer
| Parameter | Group | N |
Expression of Hsp90-beta |
Expression of annexin A1 |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Low (%) | Moderate (%) | High (%) | χ2value | Pvalue | Low (%) | Moderate (%) | High (%) | χ2value | Pvalue | |||
| Gender |
|
|
|
|
|
|
|
|
|
|
|
|
| |
Male |
73 |
12(16.4) |
22(30.1) |
39(53.4) |
4.49 |
0.105 |
18(24.7) |
26(35.6) |
29(39.7) |
5.09 |
0.078 |
| |
Female |
23 |
2(8.7) |
3(13) |
18(78.3) |
2(8.7) |
6(26.1) |
15(65.2) |
||||
| Ages |
|
|
|
|
|
|
|
|
|
|
|
|
| |
<60 |
54 |
8(14.8) |
13(24.1) |
33(61.1) |
0.251 |
0.882 |
8(14.8) |
20(37) |
26(48.1) |
2.798 |
0.247 |
| |
≥60 |
42 |
6(14.3) |
12(28.6) |
24(57.1) |
12(28.6) |
12(28.6) |
18(42.9) |
||||
| Smoking |
|
|
|
|
|
|
|
|
|
|
|
|
| |
0 |
37 |
3(8.1) |
6(16.2) |
28(75.7) |
8.28 |
0.082 |
5(13.5) |
10(27) |
22(59.5) |
3.856 |
0.248 |
| |
0.1–40 |
12 |
1(8.33) |
5(41.67) |
6(50) |
2(16.7) |
5(41.7) |
5(41.7) |
||||
| |
>40 |
47 |
10(21.3) |
14(29.8) |
23(48.9) |
13(27.7) |
17(36.2) |
17(36.2) |
||||
| Histology |
|
|
|
|
|
|
|
|
|
|
|
|
| |
LAC |
39 |
8(20.5) |
9(23.1) |
22(56.4)★ |
8.16 |
<0.05 |
7(17.9) |
9(23.1) |
23(59)▴ |
7.513 |
<0.05 |
| |
LSCC |
41 |
5(12.2) |
13(31.7) |
23(56.1)★ |
10(24.4) |
19(46.3) |
12(29.3)▴ |
||||
| |
SCLC |
11 |
1(9.1) |
1(9.1) |
9(81.82)★ |
2(18.2) |
2(18.2) |
7(63.6)▴ |
||||
| |
Others |
5 |
0(0) |
2(40) |
3(60) |
1(20) |
2(40) |
2(40) |
||||
| Pathological grade |
|
|
|
|
|
|
|
|
|
|
|
|
| |
Poorly |
26 |
1(3.8) |
4(15.4) |
21(80.8) |
31.26 |
<0.0005 |
2(7.7) |
2(7.7) |
22(84.6) |
38.26 |
<0.0005 |
| |
Moderately |
33 |
1(3.03) |
12(36.36) |
20(60.61) |
5(15.2) |
21(63.6) |
7(21.2) |
||||
| |
Well |
22 |
11(50) |
6(27.3) |
5(22.7) |
10(45.5) |
5(22.7) |
7(31.8) |
||||
| |
Undifferentiated |
15 |
1(6.67) |
3(20) |
11(73.33) |
3(20) |
4(26.7) |
8(53.3) |
||||
| Lymphatic invasion |
|
|
|
|
|
|
|
|
|
|
|
|
| |
N0 |
41 |
12(29.3) |
18(43.9) |
11(26.8)★★ |
31.02 |
<0.0005 |
17(41.5) |
13(31.7) |
11(26.8)▴▴ |
19.97 |
<0.0005 |
| |
N1 |
40 |
1(2.5) |
5(12.5) |
34(85) ★★ |
2(5.5) |
17(34.5) |
21(60) ▴▴ |
||||
| |
N2 |
11 |
0(0) |
2(18.2) |
9(81.8) ★★ |
1(9.1) |
1(9.1) |
9(81.82)▴▴ |
||||
| |
N3 |
4 |
0(0) |
0(0) |
4(100) ★★ |
0(0) |
0(0) |
4(100) ▴▴ |
||||
| hydrothorax |
|
|
|
|
|
|
|
|
|
|
|
|
| |
Absent |
82 |
13(15.9) |
23(28) |
46(56.1) |
2.51 |
0.285 |
18(22) |
29(35.4) |
35(42.7) |
2.25 |
0.324 |
| |
Present |
14 |
1(7.1) |
2(14.3) |
11(78.6) |
2(14.3) |
3(21.4) |
9(64.3) |
||||
| T stage |
|
|
|
|
|
|
|
|
|
|
|
|
| |
T1 – T2 |
57 |
11(19.3) |
22(38.6) |
24(42.1) |
14.72 |
0.001 |
17(29.8) |
23(40.4) |
17(29.8) |
14.83 |
0.001 |
| |
T3 – T4 |
28 |
2(7.1) |
2(7.1) |
24(85.7) |
1(3.6) |
7(25) |
20(71.4) |
||||
| |
Unavailable |
11 |
1(9.1) |
1(9.1) |
9(81.82) |
2(18.18) |
2(18.18) |
7(63.64) |
||||
| pTNM |
|
|
|
|
|
|
|
|
|
|
|
|
| |
IB |
3 |
1(33.3) |
2(66.7) |
0(0)● |
11.449 |
0.022 |
0(0) |
3(100) |
0(0)●● |
9.97 |
0.008 |
| |
IIA-IIB |
53 |
10(18.9) |
19(35.8) |
24(45.3)● |
16(30.2) |
20(37.7) |
17(32.1)●● |
||||
| |
IIIA-IIIB |
25 |
2(8) |
3(12) |
20(82)● |
2(8) |
6(24) |
17(68)●● |
||||
| |
IV |
4 |
0(0) |
0(0) |
4(100)● |
0(0) |
1(25) |
3(75)●● |
||||
| |
Unavailable |
11 |
1(9.1) |
1(9.1) |
9(81.82) |
2(18.18) |
2(18.18) |
7(63.64) |
||||
| Imaging |
|
|
|
|
|
|
|
|
|
|
|
|
| |
Central |
43 |
5(11.63) |
15(34.88) |
23(53.49) |
2.68 |
0.261 |
11(20.9) |
16(41.9) |
16(37.2) |
2.07 |
0.356 |
| |
Ambient |
49 |
9(18.37) |
10(24.49) |
30(57.14) |
8(20.4) |
16(32.7) |
25(46.9) |
||||
| Unavailable | 4 | 0(0) | 0(0) | 4(100) | 1(25) | 0(0) | 3(75) | |||||
★p < 0.05, SCLC compared with LSCC and LAC, respectively; ▴p < 0.05, LSCC compared with LAC and SCLC, respectively; ★★p<0.0005, N0 compared with N1, N2, and N3, respectively; ▴▴p<0.0005, N0 compared with N1, N2, and N3, respectively; ●p = 0.022, IB and IIA-IIB compared with IIIA-IIIB and IV, respectively; ●●p = 0.022, IB and IIA-IIB compared with IIIA-IIIB and IV, respectively; LAC, lung adenocarcinoma; LSCC, lung squamous cell carcinoma; SCLC, small cell lung cancer; LCLC, large cell lung cancer; Smoking, pack years of smoking.