Table 1.
Genetic, demographic and Clinical background of 2009 pdm H1N1 influenza strains
|
A/Nanchang/8002/2009 (NC2) |
A/Nanchang/8008/2009 (NC8) |
A/Nanchang/8011/2009 (NC11) |
||
|---|---|---|---|---|
| Day of sample collection |
9 Dec 2009 |
19 Dec 2009 |
22 Dec 2009 |
|
| Age (yrs) |
27 |
15 |
33 |
|
| Gender |
M |
F |
F |
|
| Temperature (oC) |
39.4 |
38.5 |
NA |
|
| Hospitalization |
✓ |
✓ |
✓ |
|
| Complications |
|
|
NA |
|
| Antiviral Treatment |
✓ |
|
|
|
| Lethality in mice |
Severe |
Mild |
Severe |
|
| Viral loads in mice lungs |
High |
Low |
High |
|
| Replication in A549 cells |
High |
Moderate |
High |
|
|
£TCID50/ml |
1 x 104.83 |
1 x 104.33 |
ND |
|
| EID50/ml |
1 x 106.4 |
1 x 107.75 |
1 x 106.4 |
|
|
€PB2 |
Genbank ID |
JF800142 |
CY089613 |
CY089621 |
| V227I |
|
✓ |
|
|
| |
V295L |
|
|
✓ |
| |
R299K |
|
✓ |
|
| |
I310R |
|
|
✓ |
| |
K353R |
|
|
✓ |
| |
N556K |
|
|
✓ |
| |
T588I |
|
|
✓ |
| |
K660R |
✓ |
|
|
|
€PB1 |
Genbank ID |
JF800143 |
CY089614 |
CY089622 |
| T257A |
✓ |
|
|
|
|
€PA |
Genbank ID |
CY089607 |
CY089615 |
CY089623 |
| A70V |
|
✓ |
✓ |
|
| P224S |
✓ |
✓ |
✓ |
|
| |
E243G |
|
✓ |
|
| |
E319V |
✓ |
|
|
| D547E | ✓ | |||
£Observed in MDCK cells, NA: not available, ND: not detected, €Mutations are compared with prototypic strain: A/California/07/2009 H1N1.