Table 2.
Urea (mg/dl) | Uric acid (mg/dl) | |||
---|---|---|---|---|
Groups | 12 h | 24 h | 12 h | 24 h |
CONTROL | 48 ± 3.9 | 28 ± 2.7 | 12.7 ± 0.19 | 11 ± 0.16 |
CYP -0.06 mg/kg bw | 47.5 ± 4 | 19 ± 1.4a,d | 9 ± 0.12a,d | 9.8 ± 0.19a,d |
CYP-0.12 mg/kg bw | 42 ± 2.3 | 20 ± 1.6d | 9.8 ± 0.2a,d | 9.9 ± 0.12a,d |
CYP-0.30 mg/kg bw | 39 ± 3.3a,d | 25 ± 2.2 | 10.1 ± 0.22a,d | 10.1 ± 0.17a,d |
CYP-0.60 mg/kg bw | 40 ± 2.6a,c | 26 ± 1.7 | 10.4 ± 0.16a,d | 10.5 ± 0.26a |
CAR-0.48 mg/kg bw | 46.5 ± 4 | 25 ± 1.8 | 13.1 ± 0.14 | 13.6 ± 0.19b,d |
CAR-0.96 mg/kg bw | 38 ± 2.5a,d | 15 ± 1.1b,d | 14 ± 0.21d | 14 ± 0.43b,d |
CAR-2.4 mg/kg bw | 43 ± 2.6 | 20 ± 1.0d | 14.4 ± 0.26a,d | 14.3 ± 0.33b,d |
CAR-4.8 mg/kg bw | 46 ± 4.1 | 16 ± 0.9b,d | 15 ± 0.28a,d | 14.5 ± 0.35b,d |
CYP-0.06 + CAR-0.48 mg/kg bw | 48 ± 2 | 26 ± 1.7 | 12 ± 0.28d | 10.9 ± 0.3 |
CYP-0.12 + CAR-0.96 mg/kg bw | 47 ± 2 | 29.5 ± 2.3 | 13 ± 0.21 | 11.2 ± 0.2 |
CYP-0.30 + CAR-2.4mg/kg bw | 48 ± 1.8 | 29.5 ± 1.3 | 13.1 ± 0.22 | 11.8 ± 0.22d |
CYP-0.60 + CAR-4.8mg/kg bw | 34 ± 2.5b,d | 25 ± 1.9 | 13.7 ± 0.22d | 12 ± 0.21d |
Values are mean ± SEM from 6 rats in each group.
P < 0.05,
P < 0.01 and
eP < 0.001: Compared between the control and treated groups.
P < 0.05 and
P < 0.01: Compared between the treated groups. Data analysed by one-way anova followed by Dunnett test.