Table 2.
Effects of treatment with bark extract of Bathysa cuspidata extract (BCE) on metabolic parameters of rats exposed to CCl4
| Groups | AST (U/l) | ALT (U/l) | GGT (U/l) | T-bilirubin (mg/dl) |
|---|---|---|---|---|
| G1 | 718.71 ± 142.34a | 144.10 ± 35.47a | 12.14 ± 6.96a | 0.61 ± 0.34a |
| G2 | 620.85 ± 116.52a | 126.82 ± 30.11a | 8.57 ± 2.57a | 0.47 ± 0.16a |
| G3 | 87.85 ± 20.86c | 47.58 ± 5.19c | 3.51 ± 1.00b | 0.18 ± 0.10b |
| G4 | 482.71 ± 118.30a | 118.91 ± 28.77a | 3.71 ± 1.79b | 0.50 ± 0.24a |
| G5 | 166.14 ± 44.99b | 69.21 ± 6.35b | 3.01 ± 1.25b | 0.40 ± 0.13a |
| G6 | 52.11 ± 16.95c | 42.29 ± 4.50c | 2.57 ± 0.97b | 0.20 ± 0.10b |
AST, aspartate aminotransferase; ALT, alanine aminotransferase; GGT, γ-glutamyl transferase; T-bilirubin, total bilirubin. Liver injury was induced by intraperitoneal administration of CCl4 (60% v/v, 1 ml/kg) every 48 h for 12 days. Group 1 (G1): CCl4; Group 2 (G2): dimethyl sulfoxide (DMSO) + CCl4; Group 3 (G3): BCE (400 mg/kg); Group 4 (G4): BCE 200 + CCl4; Group 5 (G5): BCE 400 + CCl4; Group 6 (G6): DMSO. Data are expressed as mean ± SD. Different letters in the columns indicate statistical difference between groups (P < 0.05), and groups with the same letter do not differ statistically, one-way anova.