Table 1.
DNA sites that were found hypermethylated in twins with systemic sclerosis (SSc) and that had similar profiles in concordant twins. For each site the start–end location, the chromosome position and the target gene are specified. In some cases, multiple sites have the same target gene
| Start | End | Position | Target gene | Gene part | |
|---|---|---|---|---|---|
| 1 | 21868249 | 21868298 | Xp22.11 | SMS | Promoter |
| 2 | 21868349 | 21868398 | Same as 1 | ||
| 3 | 24944225 | 24944274 | Xp21.3 | ARX | CpG island |
| 4 | 24944125 | 24944174 | Same as 3 | ||
| 5 | 47305466 | 47305515 | Xp11.23 | ARAF | CpG island |
| 6 | 47305566 | 47305615 | Same as 5 | ||
| 7 | 48980151 | 48980208 | Xp11.23 | CCDC22 | Body |
| 8 | 52794239 | 52794288 | Xp11.22 | SSX2 | Promoter |
| 9 | 52794039 | 52794100 | Same as 8 | ||
| 10 | 52793839 | 52793895 | Same as 8 | ||
| 11 | 71268623 | 71268672 | Xq13.1 | RGAG4 | CpG island |
| 12 | 77246607 | 77246656 | Xq21.1 | PGK1 | CpG island |
| 13 | 77246607 | 77246656 | Same as 12 | ||
| 14 | 104355356 | 104355413 | Xq22.3 | IL1RAPL2 | Body |
| 15 | 128867440 | 128867489 | Xq25 | UTP14A | CpG island |
| 16 | 148522050 | 148522099 | Xq28 | HSFX1 | Promoter |
| 17 | 149487626 | 149487675 | Xq28 | MTM1 | CpG island |
| 18 | 153360053 | 153360102 | Xq28 | LAGE3 | Promoter |
CpG: cytosine–guanine–dinucleotide.