Table 2.

DNA sites that were found hypomethylated in twins with systemic sclerosis (SSc) and that had similar profiles in concordant twins. For each site the start–end location, the chromosome position and the target gene are specified. In some cases, multiple sites have the same target gene

	Start	End	Position	Target gene	Gene part
1	103883076	103883125	Xq22.3	IL1RAPL2	Body
2	103883176	103883225	Same as above
3	13087308	13087357	Xp22.2	See results
4	13087708	13087757	Xp22.2	See results
5	126140539	126140588	Xq25	See results
6	126140739	126140788	Same as above
7	2429530	2429579	Xp22.33	ZBED1	Promoter
8	23982786	23982835	Xp22.11	EIF2S3	CpG island
9	41077310	41077359	Xp11.4	DDX3X	CpG island
10	47226194	47226247	Xp11.3	ZNF41	Body
11	118253590	118253639	Xq24	PGRMC1	CpG island
12	118592857	118592906	Xq24	UBE2A	CpG island
13	129230204	129230253	Xq25	ZNF280C	CpG island
14	129864954	129865003	Xq26.1	ENOX2	Promoter
15	133759124	133759176	Xq26.3	FAM122C	Promoter
16	133991162	133991218	Xq26.3	FAM127C	Promoter
17	134532227	134532289	Xq26.3	DDX26B	Body
18	134532327	134532376	Same as 17
19	134532427	134532476	Same as 17
20	134532627	134532676	Same as 17
21	148429003	148429052	Xq28	CXorf40A	Promoter
22	148429303	148429352	Same as 21
23	148429403	148429452	Same as 21
24	152712287	152712338	Xq28	SSR4	CpG island
				IDH3G	CpG island
25	152712387	152712436	Same as above

CpG: cytosine–guanine–dinucleotide.