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. 2012 Sep 5;32(36):12421–12430. doi: 10.1523/JNEUROSCI.6381-11.2012

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Copyright © 2012 the authors 0270-6474/12/3212421-10$15.00/0

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Figure 9. — A, Noise trauma decreases the formation of RhoA/p140mDia complexes. Complexes of RhoA with p140mDia were detected by immunoprecipitation (IP) with an antibody against RhoA, followed by immunoblotting (IB) with an antibody to p140mDia. The membrane was then immunoblotted with the RhoA antibody as a control for the amount of RhoA in the IP assay. The band densities of complexes of RhoA/p140mDia decreased after noise exposure compared with the control group (p < 0.05; n = 3). B, Total p140mDia decreased 3 h postnoise exposure. The total amount of p140mDia in the cochlear homogenates was detected by IB with p140mDia. GAPDH serves as a loading control. The band densities of p140mDia decreased postnoise exposure compared with controls (p < 0.01; n = 3).