TABLE 1.
Patient characteristics, phenotypic characteristics, identification and antibiotic susceptibilities of the eight non-H. influenzae blood culture isolates
| Parameter | Result for patient:
|
|||||||
|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | |
| Yr of isolation | 1996 | 1996 | 1998 | 1999 | 1999 | 2000 | 2000 | 2000 |
| Sex/age (yr) | F/83 | M/32 | M/62 | F/70 | M/48 | M/49 | F/65 | F/78 |
| Underlying condition(s) | Clostridium difficile colitis during the episode of bacteremia | Intravenous drug abuser | Fractured left medial malleolus due to accidental injury 1 week earlier | Diabetes mellitus, hypertension, intracerebral hemorrhage | Intravenous drug abuser, prosthetic valvular replacement, emphysema | Peptic ulcer treated several years earlier | Hypertension, diabetes mellitus, hyperlipidemia, hypertrophic obstructive cardiomyopathy | Carcinoma of cervix, vesicovaginal fistula, left ureteric obstruction |
| Diagnosis | Primary bacteremia | Bacteremic empyema | Bacteremic osteomyelitis of left distal tibia | Primary bacteremia | Infective endocarditis | Bacteremic spondylitis and discitis | Primary bacteremia | Bacteremic left pyelonephritis |
| Complication | Septic shock | None | None | None | None | None | None | Acute renal failure |
| No. of positive blood cultures | 1 | 1 | 1 | 2 | 3 | 2 | 1 | 1 |
| Type of bacteremia (concomitant isolates) | Monomicrobial | Polymicrobial (Streptococcus intermedius, Streptococcus sanguinis) | Monomicrobial | Monomicrobial | Monomicrobial | Monomicrobial | Polymicrobial (Streptococcus anginosus, Bacteroides fragilis, Eikenella corrodens) | Monomicrobial |
| X factor requirement | − | − | − | − | − | − | − | − |
| V factor requirement | + | + | − | + | + | + | − | + |
| Hemolysis of horse blood | − | − | − | − | − | + | − | − |
| CO2 enhancement of growth | − | − | − | − | − | − | + | − |
| Catalase | − | − | − | + | − | + | − | − |
| Indole production | − | − | − | − | − | − | − | − |
| Identification by Vitek system (NHI) | 95% H. influenzae VIII | 56% Actinobacillus actinomycetemcomitans, 40% Neisseria subflava | 62% H. paraphrophilus, 37% H. aphrophilus | 98% H. parainfluenzae I | 62% H. paraphrophilus, 37% H. aphrophilus | 95% H. parainfluenzae III | 67% H. ducreyi, 29% Kingella kingae | 62% H. paraphrophilus, 37% H. aphrophilus |
| Identification by 16S rRNA sequencing | H. segnis | H. segnis | H. aphrophilus | H. parainfluenzae | H. paraphrophilus | H. parainfluenzae | H. aphrophilus | H. segnis |
| Antibiotic susceptibilitya | ||||||||
| Ampicillin | S | S | S | S | S | S | S | S |
| Cefotaxime | S | S | S | S | S | S | S | S |
| Imipenem | S | S | S | S | S | S | S | S |
| Cotrimoxazole | S | S | S | S | S | M | S | S |
| Chloramphenicol | S | S | S | S | S | S | S | S |
a
S, sensitive; M, intermediate resistant.