TABLE 1.
Percent agreement of YeastOne colorimetric MICs of six antifungal agents with reference MIC rangesa
| NCCLS QC isolate | Antifungal agent | Reference MIC range (μg/ml) at incubation time of:
|
% YeastOne MICs within range at incubation time of:
|
||
|---|---|---|---|---|---|
| 24 h | 48 h | 24 h | 48 h | ||
| C. krusei ATCC 6258 | Caspofungin | 0.12-1 | 0.25-1 | 100 | 96 |
| Posaconazole | 0.06-0.5 | 0.12-1 | 100 | 96 | |
| Ravuconazole | 0.06-0.5 | 0.25-2 | 100 | 100 | |
| Voriconazole | 0.06-0.5 | 0.25-1 | 100 | 100 | |
| Fluconazole | 8-64 | 16-128 | 100 | 100 | |
| Amphotericin B | 0.5-2 | 1-4 | 100 | 100 | |
| C. parapsilosis ATCC 22019 | Caspofungin | 0.25-1 | 0.5-4 | 100 | 100 |
| Posaconazole | 0.06-0.25 | 0.06-0.25 | 100 | 100 | |
| Ravuconazole | 0.016-0.12 | 0.03-0.25 | 85 | 96 | |
| Voriconazole | 0.016-0.12 | 0.03-0.25 | 100 | 100 | |
| Fluconazole | 0.5-4 | 1-4 | 96 | 22 | |
| Amphotericin B | 0.25-2 | 0.5-4 | 100 | 100 | |
Tests were performed 27 times for each QC isolate in three centers.