Table 3.

Replication study results.

SNP	Chr	Position	Nearest Gene	Replication Meta-analysis P-values				Meta-analysis + Replication P-values
				Eur Am	Afr Am/Afr Carib	Latino	Overall
Replicated Associations
rs1101999	1	157,199,179	PYHIN1	NA	0.0028	0.28	0.64	3.9×10−9^
rs3771180	2	102,323,780	IL1RL1	0.17	0.0018	2.5×10−5	5.3×10−7	1.5×10−15
rs1837253	5	110,429,771	TSLP	0.0076	0.012	0.0010	1.59×10−6	1.0×10−14
rs2381416	9	6,183,455	IL33	0.0026	0.010	0.0034	1.3×10−6	1.7×10−12
rs11078927	17	35,317,931	GSDMB	7.4×10−7	0.86	4.1×10−7	1.5×10−8	2.2×10−16
Non-replicated Associations
rs4845783	1	150,759,183	CRCT1	0.25	0.74	0.24	0.15	6.2×10−6
rs2017908	3	188,900,662	RTP2	0.25	0.56	0.24	0.88	0.0030+
rs11735820	4	66,181,611	EPHA5	0.29	0.37	0.52	0.15	0.010
rs10064618	5	153,752,482	GALNT10	0.30	0.69	0.52	0.32	1.7×10−4+
rs2453626	8	101,207,073	FBXO43	0.71	0.66	0.06	0.28	0.0049
rs11214966	11	113,736,465	C11orf71	0.72	0.18	0.15	0.48	6.3×10−7^
rs16929496	12	25,885,071	RASSF8	0.44	0.59	0.28	0.97	3.7×10−4
rs335016	19	35,065,232	C19orf2	0.83	0.88	0.75	1.00	0.0018+

SNP rs1101999 in PYHIN1 is in perfect LD with rs1102000 (Table 2) in African Americans (r²=1.0), and was used as a surrogate SNP in the replication studies (neither SNP is polymorphic in European Americans); rs3771180 used as a surrogate SNP for rs10173081 near IL1RL1. Two associated SNPs could not be assayed in the replication samples: rs4653433 near SRP9 and rs9891949 near AURKB. NA, not available.

^{^}P-value is combined for only the African American and African Caribbean populations

⁺P-value is combined for only the Latino populations