Table 2.
Characteristics of probands included in the familial aggregation analysis
| Cases (n=24380) | Controls (n=23305) | p-value | |
|---|---|---|---|
| Gender | |||
| Men | 13833 (56.7%) | 12529 (53.8%) | <0.0001 |
| Women | 10547 (43.3%) | 10776 (46.2%) | |
| Age | |||
| <30 | 73 (0.3%) | 476 (2.0%) | <0.0001 |
| 30≤age<40 | 551 (2.3%) | 1388 (6.0%) | |
| 40≤age<50 | 2551 (10.5%) | 3236 (13.9%) | |
| 50≤age<60 | 5458 (22.4%) | 5764 (24.7%) | |
| 60≤age<70 | 7813 (32.3%) | 7012 (30.1%) | |
| 70≤age<80 | 6480 (26.6%) | 4689 (20.1%) | |
| 80+ | 1454 (5.9%) | 740 (3.2%) | |
| Race/Ethnicity | |||
| White/Caucasian | 20069 (82.3%) | 19303 (82.8%) | <0.0001 |
| Hispanic/Latino | 440 (1.8%) | 670 (2.9%) | |
| African American | 1304 (5.4%) | 1691 (7.3%) | |
| Asian | 1656 (6.8%) | 1282 (5.5%) | |
| American Indian and Alaskan Native |
185 (0.8%) | 33 (0.1%) | |
| Hawaiian/Pacific Islander | 398 (1.6%) | 150 (0.6%) | |
| Other | 169 (0.7%) | 152 (0.7%) | |
| Missing/Unknown | 159 (0.7%) | 24 (0.1%) | |
| Education * | |||
| Low | 6332 (26.0%) | 4550 (19.5%) | <0.0001 |
| Medium | 9023 (37.0%) | 7800 (33.5%) | |
| High | 6459 (26.5%) | 8513 (36.5%) | |
| Missing | 2566 (10.5%) | 2442 (10.5%) | |
| Type of Smoker | |||
| Never | 3301 (13.5%) | 8497 (36.5%) | <0.0001 |
| Ever** | 20961 (86.0%) | 14160 (60.8%) | |
| Former | 7940 (32.6%) | 7836 (33.6%) | |
| Current | 9877 (40.5%) | 5287 (22.7%) | |
| Missing | 118 (0.5%) | 648 (2.8%) | |
| Mean Pack Years† (SD) | 44.3 (33.3) | 20.4 (25.8) | <0.0001 |
| Histology | |||
| Small cell carcinoma | 2358 (9.7%) | ||
| Non-small cell carcinomas‡ | 18616 (76.4%) | ||
| Squamous cell carcinomas | 5781 (23.7%) | ||
| Large cell carcinomas | 1099 (4.5%) | ||
| Adenocarcinoma | 9285 (38.1%) | ||
| Bronchioloalveolar carcinoma (BAC) |
896 (3.7%) | ||
| Non small cell carcinoma, not otherwise specified |
1555 (6.4%) | ||
| Carcinoma§ | 1797 (7.4%) | ||
| Carcinoid | 347 (1.4%) | ||
| Others/missing | 1262 (5.2%) |
*
Low=less than high school, medium=high school diploma or equivalent or some college, high=college degree
**
Includes former smokers, current smokers, and subjects who were either former or current smokers
†
Pack years of smoking was missing for 9.61% of cases and 14.56% for controls
‡
Non-small cell includes squamous cell, large cell, adenocarcinomas, bronchioloalveolar carcinoma , and non-small cell carcinoma, not otherwise specified
§
No further detail available