Figure 7. Protective effects of maternal OxLDL immunization in female offspring.

(A–C) Female offspring of mothers immunized with OxLDL or PBS and non-immunized controls fed 60% sucrose diet for 24 weeks (n = 27). Body weights, glucose responses and insulin responses during an OGTT at this time are shown, together with respective AUCs (insets). (D–F) A second group of female offspring was reverted to regular chow for 19 weeks after insulin resistance had been induced by 36 weeks on the sucrose diet. Body weights, plasma glucose and insulin levels (after 6 hr. fasting) were determined at 60 weeks of age. Numbers of mice with glucose levels ≥230 mg/dl and total number in each group are indicated in the bars of panel E.