Table 1. Effect of maternal OxLDL immunization on hepatic expression of genes of relevance for diabetes.
Gene | Fold Regulation | P |
Adrenergic receptor, alpha 1a | −1.76 | 0.02 |
Interleukin 10 | −2.10 | 0.09 |
Peroxisome proliferator activated receptor alpha | −1.58 | 0.05 |
Solute carrier family 2 (facilitated glucose transporter), member 4 | −2.83 | 0.04 |
Tribbles homolog 3 | −1.99 | 0.04 |
mRNA expression of genes known to be regulated in diabetic conditions was assessed by commercial gene array in the liver of male offspring of OxLDL-immunized and control mice after 28 weeks on 60% sucrose diet (experiment #4). Only genes significantly regulated more than 1.5 fold are shown. IL-10 is included even though it failed to reach significance.