Table 1. Cardiac parameters collected after M-mode ultrasound evaluation of mice.
| Parameter | Treatment | ||||
| Veh. | iE 50 | iE 150 | iE 200 | iE-Lys | |
| BW (g) | 28.9±0.7 | 28.9±0.8 | 27.7±0.3 | 28.5±0.6 | 26.5±0.8 |
| HW (mg) | 222.6±10.9 | 226.7±28.4 | 223.8±16.6 | 233.5±20.5 | 197.0±26.0 |
| HR (bpm) | 442.8±8.7 | 460.8±1.3 | 437.8±16.8 | 409.6±4.7* | 437.2±4.5 |
| EF (%) | 74.6±1.1 | 55.4±1.7* | 44.4±0.4*** | 44.4±0.9*** | 69.2±9.6 |
| FS (%) | 38.0±1.5 | 28.3±0.9*** | 22.1±0.9*** | 25.5±2.7*** | 39.1±7.6 |
| LVESD (mm) | 2.2±0.1 | 2.3±0.2 | 2.8±0.1 | 2.8±0.3 | 2.3±0.5 |
| LVEDD (mm) | 3.8±0.1 | 3.8±0.1 | 3.8±0.1 | 3.9±0.3 | 3.8±0.4 |
| SV (mL) | 16.4±0.9 | 18.4±1.5 | 22.8±1.9*** | 28.4±2.4*** | 20.1±10.6 |
| DV (mL) | 60.3±4.2 | 63.6±2.1 | 60.9±2.9 | 64.8±12.7 | 62.3±15.3 |
| N | 6 | 4 | 4 | 6 | 3 |
Data are means ± SE. HW, heart weight, BW, body weight, HR heart rate, EF, left-ventricle ejection fraction, FS, fractional shortening, LVESD, left-ventricle end-systolic diameter; LVEDD, left-ventricle end-diastolic diameter; SV, systolic volume; DV, diastolic volume;
**
p<0.01,
***
p<0.001 Vehicle (Veh.) vs. iE (50, 150 or 200 µg iEDAP treated mice for two weeks).