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. 2012 Sep 18;7(9):e45691. doi: 10.1371/journal.pone.0045691

Figure 3. Simvastatin treatment in db/db mice.

Figure 3

A–B: Dyslipid metabolism was significantly improved after treatment with Simvastatin in (A) serum cholesterol and (B) triglycerides. C: The levels of glucose were not changed. D: The levels of albuminuria were also remarked decreased in db/db mice. E: The fibronectin score on histology did not show a significant difference between db/db mice with and without Simvastatin treatment. F: The expression of H-FABP was significantly decreased in db/db mice with Simvastatin treatment compared to db/db mice without Simvastatin treatment. G–J: histological changes were shown with Simvastatin treatment in (G) db/m mice, (H) db/db mice without Simvastatin treatment, (I) db/db mice with Simvastatin treatment and (J) quantitative changes in G/B ratio (ratio of glomerular and Bowman's capsule volume) showed a remarked decrement in db/db mice with Simvastatin treatment. Data are presented as the mean ± SD. * P<0.05; ** P<0.01 versus db/db mice without Simvastatin treatment.