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In comparison to age-matched C57BL/6 wildtype littermates JAM-C−/− C57BL/6 mice are often smaller and display a hydrocephalus. B Histological analysis of hemalaun-stained brain cryosections reveals greatly enlarged lateral ventricles (arrows), a strikingly thinned cortex and overall alteration of brain anatomy in JAM-C−/− C57BL/6 mice.
