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. 2012 Sep 18;7(9):e45619. doi: 10.1371/journal.pone.0045619

Figure 6. Hydrocephalus in JAM-C−/− C57BL/6 mice is accompanied by loss of cortical layering.

Figure 6

Immunostaining for neurofilament (NF) together with Tuj1 reveals loss of cortical layering in JAM-C−/− C57BL/6 mice (hydrocephalus score 1 shown; 5 C and D) when compared to wild type littermates (5 A and B). Inserts in B and D show pyramidal cells. Note that in the JAM-C−/− C57BL/6 mice no axonal and dendritic processes are visible. In contrast, the overall structure of the hippocampus (5 E and G) and the cerebellum (5 F and H) of JAM-C−/− C57BL/6 mice did not show any detectable alterations in NF/Tuj1 positive cells when compared to wild-type littermates. Bars as indicated.