Table 2. Volume measurements of the anterior commissure and corpus callosum during the 8 week exposure period and following 8 weeks abstinence determined from T2-weighted MRI images.
| Anterior Commissure Volume (mm3) | Corpus Callosum Volume (mm3) | |||||||
| Genu | Body | Splenium | ||||||
| Time | Air (6) | CIT (6) | Air (6) | CIT (6) | Air (6) | CIT (6) | Air (6) | CIT (6) |
| 0 Weeks | 2.33±0.15 | 2.42±0.15 | 2.73±0.30 | 2.63±0.14 | 12.65±0.68 | 12.92±0.43 | 3.49±0.29 | 4.00±0.35 |
| 4 Weeks | 2.75±0.35 | 2.73±0.37 | 3.78±0.15 | 2.27±0.11 | 17.45±1.05 | 18.07±1.02 | 5.85±0.34 | 5.29±0.25 |
| 8 Weeks | 2.66±0.29 | 3.09±0.40 | 3.79±0.19† | 3.82±0.23† | 22.01±1.33† | 20.59±0.61† | 5.97±0.34† | 5.81±0.16† |
| 16 Weeks (8 Weeks Abstinence) | 2.76±0.23 | 2.61±0.34 | 4.47±0.26 | 4.67±0.27 | 24.68±1.65 | 24.74±1.40 | 7.76±0.23 | 8.11±0.29 |
Data are expressed as mean of means (± SEM).
†
Effect of time from 0 to 8 weeks (two-way RM ANOVA with Holm–Sidak post-tests). CIT: chronic intermittent toluene.