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. 2012 Sep 18;7(9):e45043. doi: 10.1371/journal.pone.0045043

Figure 1. The effect of PKC α and βI inhibitor Gö6976 on FSH-induced mouse FEOs meiotic resumption.

Figure 1

FEOs were cultured in MEM medium only, supplemented with FSH (0.05 IU/mL) and/or PKC α and βI inhibitor Gö6976 (1–1000 nM) for the indicated period. The percent of GVBD (including polar body 1) per total number of oocytes (% GVBD) were calculated. Oocytes that had degenerated were excluded. The similar demonstrations of statistical analysis were also used in the following Figures. Data were represented as mean percentage of GVBD ± SEM of at least three independent experiments. The median number of FEOs in each group was 150. (A) The kinetics of FSH-induced FEOs meiotic resumption. **P<0.01 and ***P<0.001 compared with each corresponding time point in the control groups. (B) Gö6976 dose-dependently inhibited the function of FSH. Groups with a different letter are significantly different (P<0.05). G, Gö6976; F, FSH.