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. 2012 Sep 18;7(9):e45122. doi: 10.1371/journal.pone.0045122

Figure 5. Knockdown EpoR suppresses 786-0 tumor growth in nude mice.

Figure 5

Nude mice were subcutaneously inoculated with 2×106 parental 786-0 cells (Control, n = 6), 786-0 cells stably expressing negative siRNA (Neg SiRNA, n = 7), or 786-0 cells stably expressing EpoR siRNA (EpoR siRNA, n = 10). (A) (B) Tumor sizes after the inoculation for 10 weeks. (C) Changes of tumor size within 10 weeks (★★: P<0.01, ★★★: P<0.001). (D) HE-stained xenograft slides showed the histology of clear cell RCC. Inserts ×400.