Table 1. Parameters values for the mathematical model.

Rate constant	Description	Value	Reference
	Rate constant of E2F production by a synergy between Myc and E2F		[25]
	Michaelis constant of Myc in transactivation		[25]
	Michaelis constant of E2F in transactivation		[25]
	Rate constant of basal E2F production by Myc		[25]
	Phosphorylation rate of Rb by CycD-Cdk4/6 complex		[25]
	Michaelis constant of Rb in CycD-Cdk4/6-dependent phosphorylation		[25]
	Phosphorylation rate of Rb by CycE-Cdk2 complex		[25]
	Michaelis constant of Rb in CycE-Cdk2-dependent phosphorylation		[25]
	Degradation rate of E2F		[25]
	Associate rate of Rb and E2F		[25]
	Rate constant of miR449 production by E2F		[48]
	Degradation rate of miR449		[48]
	Rate constant of Myc production by growth factor		[25]
	Michaelis constant of growth factor		[25]
	Degradation rate of Myc		[25]
	Inhibition rate of Myc by miR449		Estimated
	Rate constant of CycD-Cdk4/6 complex production by growth factor		[25]
	Rate constant of CycD-Cdk4/6 complex production by Myc		[25]
	Degradation rate of CycD-Cdk4/6 complex		[25]
	Inhibition rate of CycD-Cdk4/6 complex by miR449		Estimated
	Production rate of CycE-Cdk2 complex by E2F		[25]
	Degradation rate of CycE-Cdk2 complex		[25]
	Inhibition rate of CycE-Cdk2 complex by miR449		Estimated
	Basal production rate of Rb		[25]
	Dephosphorylation rate of Rb		[25]
	Michaelis constant of PRb dephosphorylation		[25]
	Degradation rate of Rb		[25]
	Degradation rate of PRb		[25]
	Degradation rate of Rb/E2F complex		[25]