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. 2012 Sep 18;7(9):e43638. doi: 10.1371/journal.pone.0043638

Figure 5. The effect of silencing DKK-1 on the R. conorii-induced cytokine levels in HUVECs.

Figure 5

The figure shows the effect of different concentrations of R. conorii in HUVECs on mRNA expression (left panel) and release of protein in cell supernatants (right panel) of DKK-1 (A), IL-6 (B), IL-8 (C) and GROα (D) in the presence (siDKK, filled bars) and absence (siSCR, open bars) of siRNA probes to silence DKK-1. Silencing for 24 hours plus culturing for 6 (mRNA) and 24 (protein) hours respectively. Data are given as mean±SEM (n = 4). **P<.01, ***P<.001 vs. siSCR treated cells (control cells). †P<.05, ††P<.01 and †††P<.001 vs. un-stimulated (US) siSCR treated cells.