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. 2012 Sep 18;7(9):e43638. doi: 10.1371/journal.pone.0043638

Figure 6. The effect of silencing DKK-1 on the R. conorii-induced levels of pro- and anti-thrombotic mediators in HUVECs.

Figure 6

The figure shows the effect of different concentrations of R. conorii in HUVEC on mRNA expression of tissue factor (TF), plasminogen activator inhibitor (PAI-1) and thrombomodulin (TM) in the presence (siDKK, filled bars) and absence (siSCR, open bars) of siRNA probes to silence DKK-1 after silencing for 24 hours with additional culturing for 6 hours. Data are given as mean±SEM (n = 4). *P<.05, ***P<.001 vs. siSCR treated cells (control cells). †P<.05 and ††P<.01 vs. un-stimulated (US) siSCR treated cells.