Figure 8. Calcineurin is downstream of Hsp90 in apoptosis.

C. albicans cells were exposed to 1.25 mM H₂O₂ for 3 h in the absence or presence of CaCl₂ (1 mM) or CysA (0.08 μM). (A) and (B) are wild-type HSP90/HSP90 strain cells. (C) and (D) are tetO-HSP90/hsp90 cells in the presence of 20 μg/ml DOX. Results are shown as mean ± SD from three independent experiments. * indicates p<0.05 compared to the wild-type cells.