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. 2012 Sep 18;7(9):e45109. doi: 10.1371/journal.pone.0045109

Figure 10. A model for the role of Hsp90 in regulating apoptosis in C. albicans.

Figure 10

Upon apoptotic stimuli, Hsp90 was activated and CaMCA1 expression was elevated. Elevation in CaMCA1 expression resulted in increased caspase activity, thus inducing apoptosis. Calcineurin inhibitor cyclosporin A or Hsp90 inhibitor geldanamycin can block this pathway.