Table 3.

Top SNPs from Cumulative Dose to Event Analysis

SNP	Chr	Genea	Alleles	Discovery (n=855)			European Replication (n=154)d			African American Replication (n=117)
				MAF b	HR (95% CI)	Pc	MAF	HR (95% CI)	P	MAF	HR (95% CI)	P
rs7349683	4	EPHA5	C/T	0.36	1.63 (1.34–1.98)	9.6 × 10−7	0.32	0.96 (0.57–1.60)	0.43	0.13	1.16 (0.55–2.42)	0.35
rs4737264	8	XKR4	A/C	0.22	1.68 (1.36–2.09)	1.9×10−6	0.24	1.84 (1.02–3.33)	0.021	0.18	1.23 (0.69–2.21)	0.24
rs10771973	12	FGD4	G/A	0.31	1.57 (1.30–1.91)	2.6 × 10−6	0.33	1.72 (1.06–2.80)	0.013	0.17	1.93 (1.13–3.28)	6.7 × 10−3
rs16948748	17	PITPNA	T/G	0.04	2.37 (1.63–3.44)	2.7 × 10−6	0.02	2.65e (0.63–11.1)	0.083	0.07	1.07e (0.41–2.77)	0.45
rs16916932	10	CACNB2	C/T	0.06	2.08 (1.51–2.87)	4.3 × 10−6	0.06	0.38e (0.09–1.58)	0.082	0.08	1.13e (0.47–2.74)	0.39
rs17781082	12	GRIP1/ CAND1	C/T	0.42	1.60 (1.31–1.96)	4.3 × 10−6	0.43	1.22 (0.74–1.99)	0.22	0.21	1.32 (0.76–2.30)	0.16
rs1903216	3	BCL6/	G/A	0.48	1.59 (1.30–1.95)	5.6 × 10−6	0.41	2.08f (0.99–4.37)	0.024	0.03	3.02f (1.04–8.73)	0.016
rs2233335	8	NDRG1	T/G	0.38	0.65 (0.52–0.80)	5.2 × 10−5	0.39	0.94 (0.58–1.53)	0.41	0.23	1.40 (075–2.60)	0.14

^aIntergenic SNPs are denoted by the closest flanking annotated gene(s).

^bMinor allele frequency (MAF) was calculated within the indicated cohort.

^cP-values are two-sided for discovery analysis and one-sided for replication.

^dAs stated in the replication plan, analyses were exploratory for all except the EPHA5 and FGD4 SNPs.

^eAnalysis assumed a dominant model.

^fAnalysis assumed a recessive model.