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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: Neuropharmacology. 2012 Jul 16;64(1):268–282. doi: 10.1016/j.neuropharm.2012.07.013

Figure 4. CX1837 did not alter levels of self-grooming in B6 or BTBR and did not induce hyperactivity or sedation in a novel open field.

Figure 4

Cumulative time spent engaged in self-grooming behavior over a 10 minute session was scored by investigators blind to drug treatment. (A) B6 mice displayed their normally low levels of self-grooming after oral administration of CX1837. (B) BTBR displayed their usual high levels of repetitive self-grooming after CX1837 administration. For the grooming experiments, CX1837 was administered in 25% β-cyclodextrin in water, in accordance with lack of vehicle issues on self-grooming, discussed in the text. N = 7-10 per dose for each strain. Total distance traversed during a 30 minute test session in an Accuscan open field in BTBR and B6 was unaffected, following peanut butter delivery of vehicle (0.0 mg/kg) or CX1837 treatment at doses of 0.3 mg/kg, 1.0 mg/kg and 3.0 mg/kg in (C) B6 and (D) BTBR. Vehicle for the open field experiments was peanut butter pellets. Data for the open field graphs are shown in 5 minute time bins as mean ± SEM. *p < 0.05 as compared to vehicle. N=9-13 per strain per dose. See Supplementary Material S3 for additional open field parameters.