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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: CA Cancer J Clin. 2012 May 10;62(5):309–335. doi: 10.3322/caac.20132

FIGURE 1.

FIGURE 1

Key Events in the History of Cancer Immunotherapy.1–7 An earlier publication for Coley can be found at: Coley WB. The treatment of inoperable sarcoma by bacterial toxins (the mixed toxins of the Streptococcus erysipelas and the Bacillus prodigiosus). Proc R Soc Med. 1910;3(Surg Sect):1–48. BCG indicates Bacillus Calmette-Guerin; mAbs, monoclonal antibodies; IFN-α, interferon-α; HCL, hairy cell leukemia; IL-2, interleukin-2; RCC, renal cell carcinoma; Peg IFN, pegylated IFN; CTLA-4, cytotoxic T lymphocyte antigen-4; MAGE-1, melanoma-associated antigen 1. Adapted from Kirkwood JM, Tarhini AA, Panelli MC, et al. Next generation of immunotherapy for melanoma. J Clin Oncol. 2008;26:3445–3455.