Skip to main content
. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: CA Cancer J Clin. 2012 May 10;62(5):309–335. doi: 10.3322/caac.20132

FIGURE 2.

FIGURE 2

Cross-Presentation/Determinant Spreading. Self-antigen cross-presentation is thought to be a mechanism for inducing autoimmunity, which can involve tumor antigens (and determinant spreading from an antigen immunized against to self-antigens not specifically immunized against) and normal self-antigens (such as thyroid antigens). Cell lysis in an immunogenic milieu allows endogenous antigen-presenting cells (APCs) to take up these self-antigens, cross-present them, and activate T cells with new specificities.