Table 4A.

Mean pharmacokinetics of free aflibercept

Subject	Dose (mg/kg)	t1/2 (days)	Cmax (μg/ml)	AUC 0–∞ (μg/ml*day)	Cl (mL/day/kg)	Vz (mL/kg)	Vss (mL/kg)
1	2.0	4.97	25.8	145	13.8	98.6	79.3
7	2.0	5.67	25.0	164	12.2	99.9	92.1
18	2.5	5.20	12.2	109	23.0	172.4	159.2
20	2.5	3.55	24.1	116	21.5	109.8	93.0
9	3.0	3.93	56.9	168	17.9	101.2	82.2
10	3.0	4.89	58.7	187	16.0	112.9	88.2
12	3.0	2.64	44.5	119	25.2	95.9	85.7
14	3.0	4.84	32.9	169	17.7	123.6	126.1
Mean		4.46			18.4	114	101
SD		1.00			4.5	25	28
% CV		23			25	22	28