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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: Eur J Neurosci. 2012 Jul 5;36(6):2839–2848. doi: 10.1111/j.1460-9568.2012.08202.x

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Effects of the serotonin reuptake inhibitors (SSRIs) paroxetine (A,D), citalopram (B,E) and fluoxetine (C,F) on L-DOPA-induced abnormal involuntary movements (AIMs; A–C) and rotations (D–F). Rats were treated with vehicle, paroxetine (0.5 or 1.25 mg/kg, i.p.), citalopram (3 or 5 mg/kg, i.p.) or fluoxetine (10 or 20 mg/kg, i.p.) 30 minutes prior to vehicle or L-DOPA (6 mg/kg, s.c.) + benserazide (15 mg/kg, s.c.). Summed axial, limb and orolingual (ALO) AIMs and rotations were evaluated every 10 minutes for 3 hours after L-DOPA. Values are expressed as medians (AIMs+median absolute difference) or means (+standard error of the mean). Significant differences were determined by non-parametric Friedman ANOVAs with Wilcoxon post-hocs (AIMs) or 2-way repeated measures ANOVAs (rotations) and Fischer LSD post-hocs. *p<0.05 vehicle + L-DOPA vs. paroxetine (1.25), citalopram (5) and fluoxetine (20) + L-DOPA, +p<0.05 vs. vehicle + L-DOPA vs. paroxetine (0.5), citalopram (3) and fluoxetine (10) + L-DOPA, ^p<0.05 vs. vehicle + L-DOPA vs. paroxetine (0.3), citalopram (1) and fluoxetine (5) + L-DOPA.