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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: Eur J Neurosci. 2012 Jul 5;36(6):2839–2848. doi: 10.1111/j.1460-9568.2012.08202.x

Figure 3.

Figure 3

Figure 3

Figure 3

Figure 3

The effects the direct dopamine receptor agonist apomorphine (A,B) and their modulation by serotonin reuptake inhibitors (SSRIs) paroxetine, citalopram and fluoxetine (C,D) on abnormal involuntary movements (AIMs; A,C) and rotations (B,D). In experiment 1, rats (n=6) were treated with vehicle or apomorphine (0.025, 0.05 or 0.1 mg/kg, s.c.). In experiment 2 rats were pretreated with vehicle, paroxetine (0.5 mg/kg, i.p.), citalopram (3 mg/kg, i.p.) or fluoxetine (10 mg/kg, i.p.) 30 minutes prior to apomorphine (0.05 mg/kg, s.c.). Summed axial, limb and orolingual (ALO) AIMs and rotations were evaluated every 10 minutes for 90 minutes after apomorphine. Values are expressed as medians (AIMs+median absolute difference) or means (+standard error of the mean). Significant differences were determined by non-parametric Friedman ANOVAs with Wilcoxon post-hocs (AIMs) or 2-way repeated measures ANOVAs (rotations) and Fischer LSD post-hocs. *p<0.05 vehicle vs. apomorphine (0.1) +p<0.05 vehicle vs. apomorphine (0.05), ^p<0.05 vehicle vs. apomorphine (0.025) #p<0.05 vs. all other treatments.