Table 2.
Studies reporting on operated stage 4 patients in whom either complete gross resection (CR) or gross total resection (GTR) was attempted
| Publication | Number of operated patients | Intended level of surgery (achieved percentage between brackets) | Improved survival compared to all less extensive surgery | Improved survival of CR explicitly compared to GTR | Supported type of surgery |
|---|---|---|---|---|---|
| a. Complete gross resection (CR) | |||||
| Haase et al. [3] | 52 | CRa | Yes (S) | ND | CR |
| Chamberlain et al. [15] | 28 | CR (46 %) | Yes (S) | ND | CR |
| Kuroda et al. [16] | 24 | CRa | Yes (S) | ND | CR |
| Browne et al. [30] | 30 | CR (63 %) | Yes (NS) | ND | GTR |
| Sultan et al. [20] | 291 | CR (58 %) | Yes (S) | ND | CR |
| Escobar et al. [21] | 104 | CR (50 %) | Yes (S) | ND | CR |
| La Quaglia et al. [18] | 70 | CRb (56 %) | Yes (S) | ND | CR |
| La Quaglia et al. [19] | 141 | CRb (73 %) | Yes (S) | ND | CR |
| Adkins et al. [14] | 468 | CR (45 %) | Yes (NS) | Yes (NS) | CR |
| Koh et al. [17] | 26 | CR (38.5 %) | Yes (S) | Yes (S) | CR |
| Shorter et al. [26] | CR | No | No | GTR | |
| Castel et al. [9] | 71 | CR (55 %) | No | No | GTR |
| von Allmen et al. [27] | 69 | CRa,b | No | ND | GTR |
| von Schweinitz et al. [6] | 791 | CR (59 %) | No | ND | GTR |
| Kiely et al. [25] | 75 | CR (75 %) | No | ND | GTR |
| Le Tourneau et al. [12] | 36 | CR (33 %) | No | ND | CR |
| b. Gross total resection (GTR) | |||||
| Kaneko et al. [24] | 10 | GTR (70 %) | Yes (NS) | ND | GTR |
| Matsumura et al. [28] | 214 | GTR (64 %) | Yes (NS) | ND | GTR |
| Tsuchida et al. [29] | 92 | GTR (79 %) | Yes (S) | ND | GTR |
| McGregor et al. [10] | 107 | GTR (77 %) | No | ND | GTR |
In the 4th column, the survival of patients undergoing the intended level of surgery is compared to patients undergoing all less extensive surgery. In the 5th column, if applicable (indicated by bold letter type), survival after CR is compared to GTR
ND not determined, S significant, NS not significant
aPercentage cannot be determined
bCR according to INSS, the term GTR is used in the publication