Table 1.
Variation in the major clinical disease phenotypes with age, gender, ethnicity and location of residence
| Parameters | N | CM | P value | N | SMA | P value | N | UM | P value | N | RD | P value |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Age group (months) |
|
|
|
|
|
|
|
|
|
|
|
|
| < 60 |
562 |
41 (7.3) |
0.420 |
637 |
187 (29.4) |
0.009 |
662 |
130 (19.6) |
<0.001 |
284 |
44 (15.5) |
0.143 |
| ≥ 60 |
148 |
8 (5.4) |
158 |
30 (19.0) |
167 |
71 (42.5) |
95 |
9 (9.5) |
||||
| Gender |
|
|
|
|
|
|
|
|
|
|
|
|
| Male |
409 |
23 (5.6) |
0.449 |
469 |
118 (25.2) |
0.042 |
487 |
133 (27.3) |
0.473 |
192 |
23 (15.6) |
0.082 |
| Female |
375 |
26 (6.9) |
415 |
130 (31.3) |
432 |
109 (25.2) |
230 |
30 (10.0) |
||||
| Ethnicity |
|
|
|
|
|
|
|
|
|
|
|
|
| Bantu |
313 |
21 (6.7) |
0.996 |
358 |
98 (27.4) |
0.368 |
368 |
103 (28.0) |
0.031 |
177 |
26 (14.7) |
0.827 |
| Semi-Bantu |
352 |
23 (6.5) |
388 |
111 (28.6) |
409 |
84 (20.5) |
169 |
21 (12.4) |
||||
| Foulbe |
30 |
2 (6.7) |
30 |
5 (16.7) |
31 |
5 (16.1) |
7 |
1 (14.3) |
||||
| Location |
|
|
|
|
|
|
|
|
|
|
|
|
| Centre |
163 |
5 (3.1) |
<0.001 |
162 |
61 (37.7) |
0.004 |
163 |
20 (12.3) |
<0.001 |
39 |
11 (28.2) |
0.008 |
| Littoral |
285 |
32 (11.2) |
277 |
63 (22.7) |
288 |
19 (6.6) |
29 |
3 (10.3) |
||||
| South West |
336 |
12 (3.6) |
446 |
124 (27.8) |
469 |
203 (43.3) |
354 |
39 (11.0) |
||||
| Transmission |
|
|
|
|
|
|
|
|
|
|
|
|
| Seasonal |
163 |
5 (3.1) |
0.059 |
162 |
61 (37.7) |
0.003 |
163 |
20 (12.3) |
<0.001 |
39 |
11 (28.2) |
0.002 |
| Perennial | 621 | 44 (7.1) | 723 | 187 (25.9) | 757 | 222 (29.3) | 383 | 42 (11) | ||||
Each participant has been categorised into one group only which clinicians felt was the primary phenotype; Samples numbers in some of the clinical groups are lower because some parameter estimates were not taken.